The Calcium-Induced Regulation in the Molecular and Transcriptional Circuitry of Human Inflammatory Response and Autoimmunity

• Hoofdauteurs: Ivo R. de Seabra Rodrigues Dias (Auteur), Simon W. F. Mok (Auteur), Flora Gordillo-Martínez (Auteur), Imran Khan (Auteur), Wendy W. L. Hsiao (Auteur), Betty Y. K. Law (Auteur), Vincent K. W. Wong (Auteur), Liang Liu (Auteur)
• Formaat: Boek
• Gepubliceerd in: Frontiers Media S.A., 2018-01-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Rheumatoid arthritis synovial fibroblasts (RASFs) are fundamental effector cells in RA driving the joint inflammation and deformities. Celastrol is a natural compound that exhibits a potent anti-arthritic effect promoting endoplasmic reticulum (ER) stress mediated by intracellular calcium (Ca2+) mob...