The Calcium-Induced Regulation in the Molecular and Transcriptional Circuitry of Human Inflammatory Response and Autoimmunity

• Main Authors: Ivo R. de Seabra Rodrigues Dias (Author), Simon W. F. Mok (Author), Flora Gordillo-Martínez (Author), Imran Khan (Author), Wendy W. L. Hsiao (Author), Betty Y. K. Law (Author), Vincent K. W. Wong (Author), Liang Liu (Author)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2018-01-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Rheumatoid arthritis synovial fibroblasts (RASFs) are fundamental effector cells in RA driving the joint inflammation and deformities. Celastrol is a natural compound that exhibits a potent anti-arthritic effect promoting endoplasmic reticulum (ER) stress mediated by intracellular calcium (Ca2+) mob...