Predictive Factors of Piperacillin Exposure and the Impact on Target Attainment after Continuous Infusion Administration to Critically Ill Patients

• Main Authors: Javier Martínez-Casanova (Author), Erika Esteve-Pitarch (Author), Helena Colom-Codina (Author), Víctor Daniel Gumucio-Sanguino (Author), Sara Cobo-Sacristán (Author), Evelyn Shaw (Author), Kristel Maisterra-Santos (Author), Joan Sabater-Riera (Author), Xosé L. Pérez-Fernandez (Author), Raül Rigo-Bonnin (Author), Fe Tubau-Quintano (Author), Jordi Carratalà (Author), Ariadna Padullés-Zamora (Author)
• Format: Book
• Published: MDPI AG, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Critically ill patients undergo significant pathophysiological changes that affect antibiotic pharmacokinetics. Piperacillin/tazobactam administered by continuous infusion (CI) improves pharmacokinetic/pharmacodynamic (PK/PD) target attainment. This study aimed to characterize piperacillin PK after...