A New Phenylpyrazoleanilide, Y-320, Inhibits Interleukin 17 Production and Ameliorates Collagen-Induced Arthritis in Mice and Cynomolgus Monkeys

• Main Authors: Hiroyuki Ushio (Author), Seigo Ishibuchi (Author), Koichi Oshita (Author), Noriyasu Seki (Author), Hirotoshi Kataoka (Author), Kunio Sugahara (Author), Kunitomo Adachi (Author), Kenji Chiba (Author)
• Format: Book
• Published: MDPI AG, 2013-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Interleukin (IL)-15 and IL-17 are thought to play an important role in the pathogenesis of rheumatoid arthritis (RA) because both pro-inflammatory cytokines are found in synovial fluid of RA patients. In this study, we examined the pharmacological profiles of Y-320, a new phenylpyrazoleanilide immun...