A New Phenylpyrazoleanilide, Y-320, Inhibits Interleukin 17 Production and Ameliorates Collagen-Induced Arthritis in Mice and Cynomolgus Monkeys

• Päätekijät: Hiroyuki Ushio (Tekijä), Seigo Ishibuchi (Tekijä), Koichi Oshita (Tekijä), Noriyasu Seki (Tekijä), Hirotoshi Kataoka (Tekijä), Kunio Sugahara (Tekijä), Kunitomo Adachi (Tekijä), Kenji Chiba (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: MDPI AG, 2013-12-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Interleukin (IL)-15 and IL-17 are thought to play an important role in the pathogenesis of rheumatoid arthritis (RA) because both pro-inflammatory cytokines are found in synovial fluid of RA patients. In this study, we examined the pharmacological profiles of Y-320, a new phenylpyrazoleanilide immun...