An extension to a statistical approach for family based association studies provides insights into genetic risk factors for multiple sclerosis in the <it>HLA-DRB1 </it>gene

• Main Authors: Sadovnick A Dessa (Author), Dyment David A (Author), McMahon Roisin (Author), Ramagopalan Sreeram V (Author), Ebers George C (Author), Wittkowski Knut M (Author)
• Format: Book
• Published: BMC, 2009-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Multiple sclerosis (MS) is a complex trait in which genes in the MHC class II region exert the single strongest effect on genetic susceptibility. The principal MHC class II haplotype that increases MS risk in individuals of Northern...