Moderate SIRT1 overexpression protects against brown adipose tissue inflammation

• Main Authors: Carmen Escalona-Garrido (Author), Patricia Vázquez (Author), Paula Mera (Author), Sebastián Zagmutt (Author), Ester García-Casarrubios (Author), Ana Montero-Pedrazuela (Author), Fernanda Rey-Stolle (Author), Ana Guadaño-Ferraz (Author), Francisco J. Rupérez (Author), Dolors Serra (Author), Laura Herrero (Author), Maria Jesus Obregon (Author), Ángela M. Valverde (Author)
• Format: Book
• Published: Elsevier, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Metainflammation is a chronic low-grade inflammatory state induced by obesity and associated comorbidities, including peripheral insulin resistance. Brown adipose tissue (BAT), a therapeutic target against obesity, is an insulin target tissue sensitive to inflammation. Therefore, it is ne...