In vitro-in vivo availability of metformin hydrochloride-PLGA nanoparticles in diabetic rats in a periodontal disease experimental model

• Main Authors: Aline de Sousa Barbosa Freitas Pereira (Author), Maria Laura de Souza Lima (Author), Arnobio Antonio da Silva-Junior (Author), Emanuell dos Santos Silva (Author), Raimundo Fernandes de Araújo Júnior (Author), Agnes Andrade Martins (Author), Jovelina Samara Ferreira Alves (Author), Artur de Santana Oliveira (Author), Leandro De Santis Ferreira (Author), Emily Cintia Tossi de Araújo Costa (Author), Gerlane Coelho Bernardo Guerra (Author), Caroline Addison Carvalho Xavier de Medeiros (Author), Gerly A. C. Brito (Author), Renata Ferreira de Carvalho Leitao (Author), Aurigena Antunes de Araújo (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Context Metformin is an important oral anti-hyperglycemic used in diabetes. Polylactic-co-glycolic acid (PLGA) has been widely used due to its reliability in controlling the release of drugs. Objective This study evaluates the in vitro-in vivo availability of metformin hydrochloride-loaded polylacti...