Functional Restoration of BRCA1 Nonsense Mutations by Aminoglycoside-Induced Readthrough

• Main Authors: Renata B. V. Abreu (Author), Thiago T. Gomes (Author), Thales C. Nepomuceno (Author), Xueli Li (Author), Mateus Fuchshuber-Moraes (Author), Giuliana De Gregoriis (Author), Guilherme Suarez-Kurtz (Author), Alvaro N. A. Monteiro (Author), Marcelo A. Carvalho (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BRCA1 is a major tumor suppressor that functions in the accurate repair of DNA double-strand breaks via homologous recombination (HR). Nonsense mutations in BRCA1 lead to inactive truncated protein products and are associated with high risk of breast and ovarian cancer. These mutations generate prem...