CD40 Generation 2.5 Antisense Oligonucleotide Treatment Attenuates Doxorubicin-induced Nephropathy and Kidney Inflammation

• Päätekijät: Aaron J Donner (Tekijä), Steve T Yeh (Tekijä), Gene Hung (Tekijä), Mark J Graham (Tekijä), Rosanne M Crooke (Tekijä), Adam E Mullick (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Elsevier, 2015-01-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Preclinical and clinical data suggest CD40 activation contributes to renal inflammation and injury. We sought to test whether upregulation of CD40 in the kidney is a causative factor of renal pathology and if reduction of renal CD40 expression, using antisense oligonucleotides (ASOs) targeting CD40,...