RIPK1 and RIPK3 regulate TNFα-induced β-cell death in concert with caspase activity

• Main Authors: Christopher J. Contreras (Author), Noyonika Mukherjee (Author), Renato C.S. Branco (Author), Li Lin (Author), Meghan F. Hogan (Author), Erica P. Cai (Author), Andrew A. Oberst (Author), Steven E. Kahn (Author), Andrew T. Templin (Author)
• Format: Book
• Published: Elsevier, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Type 1 diabetes (T1D) is characterized by autoimmune-associated β-cell loss, insulin insufficiency, and hyperglycemia. Although TNFα signaling is associated with β-cell loss and hyperglycemia in non-obese diabetic mice and human T1D, the molecular mechanisms of β-cell TNF receptor signali...