Chikungunya virus dissemination from the midgut of Aedes aegypti is associated with temporal basal lamina degradation during bloodmeal digestion.

• Main Authors: Shengzhang Dong (Author), Velmurugan Balaraman (Author), Asher M Kantor (Author), Jingyi Lin (Author), DeAna G Grant (Author), Nicole L Held (Author), Alexander W E Franz (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In the mosquito, the midgut epithelium is the initial tissue to become infected with an arthropod-borne virus (arbovirus) that has been acquired from a vertebrate host along with a viremic bloodmeal. Following its replication in midgut epithelial cells, the virus needs to exit the midgut and infect...