A mitochondrial-targeted peptide ameliorated podocyte apoptosis through a HOCl-alb-enhanced and mitochondria-dependent signalling pathway in diabetic rats and in vitro

• Main Authors: Xiaoqiao Wang (Author), Dongdong Tang (Author), Yaowei Zou (Author), Xiaoyu Wu (Author), Yihua Chen (Author), Hongying Li (Author), Siqi Chen (Author), Yue Shi (Author), Hongxin Niu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mitochondria play important roles in the development of diabetic kidney disease (DKD). The SS peptide is a tetrapeptide that is located and accumulated in the inner mitochondrial membrane; it reduces reactive oxygen species (ROS) and prevents mitochondrial dysfunction. Podocytes are key cellular com...