Hippocampal Proteome of Rats Subjected to the Li-Pilocarpine Epilepsy Model and the Effect of Carisbamate Treatment

• Main Authors: José Eduardo Marques-Carneiro (Author), Daniele Suzete Persike (Author), Julia Julie Litzahn (Author), Jean-Christophe Cassel (Author), Astrid Nehlig (Author), Maria José da Silva Fernandes (Author)
• Format: Book
• Published: MDPI AG, 2017-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In adult rats, the administration of lithium-pilocarpine (LiPilo) reproduces most clinical and neuropathological features of human temporal lobe epilepsy (TLE). Carisbamate (CRS) possesses the property of modifying epileptogenesis in this model. Indeed, about 50% of rats subjected to LiPilo status e...