A disease‐associated missense mutation in CYP4F3 affects the metabolism of leukotriene B4 via disruption of electron transfer

• Main Authors: Elien Smeets (Author), Shengyun Huang (Author), Xiao Yin Lee (Author), Erika Van Nieuwenhove (Author), Christine Helsen (Author), Florian Handle (Author), Lisa Moris (Author), Sarah El Kharraz (Author), Roy Eerlings (Author), Wout Devlies (Author), Mathijs Willemsen (Author), Leoni Bücken (Author), Teresa Prezzemolo (Author), Stephanie Humblet‐Baron (Author), Arnout Voet (Author), Anne Rochtus (Author), Ann Van Schepdael (Author), Francis deZegher (Author), Frank Claessens (Author)
• Format: Book
• Published: Wiley, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Cytochrome P450 4F3 (CYP4F3) is an ω‐hydroxylase that oxidizes leukotriene B4 (LTB4), prostaglandins, and fatty acid epoxides. LTB4 is synthesized by leukocytes and acts as a chemoattractant for neutrophils, making it an essential component of the innate immune system. Recently,...