Virtual twins for model‐informed precision dosing of clozapine in patients with treatment‐resistant schizophrenia

Virtual twins for model‐informed precision dosing of clozapine in patients with treatment‐resistant schizophrenia

Abstract Model‐informed precision dosing using virtual twins (MIPD‐VTs) is an emerging strategy to predict target drug concentrations in clinical practice. Using a high virtualization MIPD‐VT approach (Simcyp version 21), we predicted the steady‐state clozapine concentration and clozapine dosage ran...

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Main Authors: Sam Mostafa (Author), Reza Rafizadeh (Author), Thomas M. Polasek (Author), Chad A. Bousman (Author), Amin Rostami‐Hodjegan (Author), Robert Stowe (Author), Prescilla Carrion (Author), Leslie J. Sheffield (Author), Carl M. J. Kirkpatrick (Author)
Format: Book
Published: Wiley, 2024-03-01T00:00:00Z.
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