Cathepsin G Induces Cell Aggregation of Human Breast Cancer MCF-7 Cells via a 2-Step Mechanism: Catalytic Site-Independent Binding to the Cell Surface and Enzymatic Activity-Dependent Induction of the Cell Aggregation

• Huvudskapare: Riyo Morimoto-Kamata (Författare, medförfattare), Sei-ichiro Mizoguchi (Författare, medförfattare), Takeo Ichisugi (Författare, medförfattare), Satoru Yui (Författare, medförfattare)
• Materialtyp: Bok
• Publicerad: Hindawi Limited, 2012-01-01T00:00:00Z.
• Ämnen: article
• Länkar: Connect to this object online.

Neutrophils often invade various tumor tissues and affect tumor progression and metastasis. Cathepsin G (CG) is a serine protease secreted from activated neutrophils. Previously, we have shown that CG induces the formation of E-cadherin-mediated multicellular spheroids of human breast cancer MCF-7 c...