Cathepsin G Induces Cell Aggregation of Human Breast Cancer MCF-7 Cells via a 2-Step Mechanism: Catalytic Site-Independent Binding to the Cell Surface and Enzymatic Activity-Dependent Induction of the Cell Aggregation

• Hlavní autoři: Riyo Morimoto-Kamata (Autor), Sei-ichiro Mizoguchi (Autor), Takeo Ichisugi (Autor), Satoru Yui (Autor)
• Médium: Kniha
• Vydáno: Hindawi Limited, 2012-01-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Neutrophils often invade various tumor tissues and affect tumor progression and metastasis. Cathepsin G (CG) is a serine protease secreted from activated neutrophils. Previously, we have shown that CG induces the formation of E-cadherin-mediated multicellular spheroids of human breast cancer MCF-7 c...