Chronic MK-801 Application in Adolescence and Early Adulthood: A Spatial Working Memory Deficit in Adult Long-Evans Rats But No Changes in the Hippocampal NMDA Receptor Subunits

• Main Authors: Libor Uttl (Author), Tomas Petrasek (Author), Hilal Sengul (Author), Marketa Svojanovska (Author), Veronika Lobellova (Author), Karel Vales (Author), Dominika Radostova (Author), Grygoriy Tsenov (Author), Hana Kubova (Author), Anna Mikulecka (Author), Jan Svoboda (Author), Ales Stuchlik (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The role of NMDA receptors in learning, memory and hippocampal function has long been recognized. Post-mortem studies have indicated that the expression or subunit composition of the NMDA glutamate receptor subtype might be related to the impaired cognitive functions found in schizophrenia patients....