Long-Term Treatment With Morphine Increases the D-Serine Content in the Rat Brain by Regulating the mRNA and Protein Expressions of Serine Racemase and D-Amino Acid Oxidase

Long-Term Treatment With Morphine Increases the D-Serine Content in the Rat Brain by Regulating the mRNA and Protein Expressions of Serine Racemase and D-Amino Acid Oxidase

Recent studies indicate that an endogenous co-agonist for an N-methyl-D-aspartate (NMDA) receptor-related glycine site, D-serine, is synthesized by serine racemase and is metabolized by D-amino acid oxidase (DAO) and that acute treatment with morphine augments the gene expression of serine racemase...

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Main Authors: Masanobu Yoshikawa (Author), Takashi Shinomiya (Author), Naoko Takayasu (Author), Hideo Tsukamoto (Author), Mitsuru Kawaguchi (Author), Hiroyuki Kobayashi (Author), Tetsuo Oka (Author), Atsushi Hashimoto (Author)
Format: Book
Published: Elsevier, 2008-01-01T00:00:00Z.
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