Autonomous interconversion between adult pancreatic α-cells and β-cells after differential metabolic challenges

• Main Authors: Risheng Ye (Author), Miao Wang (Author), Qiong A. Wang (Author), Stephen B. Spurgin (Author), Zhao V. Wang (Author), Kai Sun (Author), Philipp E. Scherer (Author)
• Format: Book
• Published: Elsevier, 2016-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Evidence hints at the ability of β-cells to emerge from non-β-cells upon genetic or pharmacological interventions. However, their quantitative contributions to the process of autonomous β-cell regeneration without genetic or pharmacological manipulations remain to be determined. Methods...