The discovery of a novel series of compounds with single-dose efficacy against juvenile and adult Schistosoma species.

• Main Authors: J Mark F Gardner (Author), Nuha R Mansour (Author), Andrew S Bell (Author), Helena Helmby (Author), Quentin Bickle (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Treatment and control of schistosomiasis depends on a single drug, praziquantel, but this is not ideal for several reasons including lack of potency against the juvenile stage of the parasite, dose size, and risk of resistance. We have optimised the properties of a series of compounds we discovered...