FOXC2 expression and epithelial-mesenchymal phenotypes are associated with castration resistance, metastasis and survival in prostate cancer

• Main Authors: Astrid Børretzen (Author), Karsten Gravdal (Author), Svein A Haukaas (Author), Christian Beisland (Author), Lars A Akslen (Author), Ole J Halvorsen (Author)
• Format: Book
• Published: Wiley, 2019-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Epithelial-mesenchymal transition (EMT) is important for tumour cell invasion and metastasis and is a feature of aggressive carcinomas. EMT is characterised by reduced E‐cadherin and increased N‐cadherin expression (EN‐switch), and increased expression of the EMT‐regulating transcription fa...