Enantioselectivity of Pentedrone and Methylone on Metabolic Profiling in 2D and 3D Human Hepatocyte-like Cells

• Main Authors: Bárbara Silva (Author), Joana Saraiva Rodrigues (Author), Ana Sofia Almeida (Author), Ana Rita Lima (Author), Carla Fernandes (Author), Paula Guedes de Pinho (Author), Joana Paiva Miranda (Author), Fernando Remião (Author)
• Format: Book
• Published: MDPI AG, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pentedrone and methylone can express stereoselectivity in toxicokinetic and toxicodynamic processes. Similarly, their chiral discrimination in metabolism, which was not yet evaluated, can result in different metabolic profiles and subsequent hepatotoxic effects. Therefore, the aim of this work was t...