Cholesterol-associated lysosomal disorder triggers cell death of hematological malignancy: Dynamic analysis on cytotoxic effects of LW-218

• Main Authors: Po Hu (Author), Hui Li (Author), Wenzhuo Sun (Author), Hongzheng Wang (Author), Xiaoxuan Yu (Author), Yingjie Qing (Author), Zhanyu Wang (Author), Mengyuan Zhu (Author), Jingyan Xu (Author), Qinglong Guo (Author), Hui Hui (Author)
• Format: Book
• Published: Elsevier, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The integrity of lysosomes is of vital importance to survival of tumor cells. We demonstrated that LW-218, a synthetic flavonoid, induced rapid lysosomal enlargement accompanied with lysosomal membrane permeabilization in hematological malignancy. LW-218-induced lysosomal damage and lysosome-depende...