Active receptor tyrosine kinases, but not Brachyury, are sufficient to trigger chordoma in zebrafish

• Main Authors: Gianluca D'Agati (Author), Elena María Cabello (Author), Karl Frontzek (Author), Elisabeth J. Rushing (Author), Robin Klemm (Author), Mark D. Robinson (Author), Richard M. White (Author), Christian Mosimann (Author), Alexa Burger (Author)
• Format: Book
• Published: The Company of Biologists, 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The aberrant activation of developmental processes triggers diverse cancer types. Chordoma is a rare, aggressive tumor arising from transformed notochord remnants. Several potentially oncogenic factors have been found to be deregulated in chordoma, yet causation remains uncertain. In particular, sus...