Analysis of epitopes on dengue virus envelope protein recognized by monoclonal antibodies and polyclonal human sera by a high throughput assay.

• Main Authors: Hong-En Lin (Author), Wen-Yang Tsai (Author), I-Ju Liu (Author), Pi-Chun Li (Author), Mei-Ying Liao (Author), Jih-Jin Tsai (Author), Yi-Chieh Wu (Author), Chih-Yun Lai (Author), Chih-Hsuan Lu (Author), Jyh-Hsiung Huang (Author), Gwong-Jen Chang (Author), Han-Chung Wu (Author), Wei-Kung Wang (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: The envelope (E) protein of dengue virus (DENV) is the major target of neutralizing antibodies and vaccine development. While previous studies on domain III or domain I/II alone have reported several epitopes of monoclonal antibodies (mAbs) against DENV E protein, the possibility of inte...