Pharmacologic Targeting of BET Proteins Attenuates Hyperuricemic Nephropathy in Rats

• Main Authors: Chongxiang Xiong (Author), Jin Deng (Author), Xin Wang (Author), Xiaofei Shao (Author), Qin Zhou (Author), Hequn Zou (Author), Shougang Zhuang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hyperuricemia is an independent risk factor for renal damage and promotes the progression of chronic kidney disease. In this study, we investigated the effect of I-BET151, a small-molecule inhibitor targeting the bromodomain and extraterminal (BET) proteins, on the development of hyperuricemic nephr...