Pharmacologic Targeting of BET Proteins Attenuates Hyperuricemic Nephropathy in Rats

• Principais autores: Chongxiang Xiong (Autor), Jin Deng (Autor), Xin Wang (Autor), Xiaofei Shao (Autor), Qin Zhou (Autor), Hequn Zou (Autor), Shougang Zhuang (Autor)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2021-02-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Hyperuricemia is an independent risk factor for renal damage and promotes the progression of chronic kidney disease. In this study, we investigated the effect of I-BET151, a small-molecule inhibitor targeting the bromodomain and extraterminal (BET) proteins, on the development of hyperuricemic nephr...