Glutathione Peroxidases: An Emerging and Promising Therapeutic Target for Pancreatic Cancer Treatment

• Main Authors: Paula Iglesias-Matesanz (Author), Carlos Lacalle-Gonzalez (Author), Carlos Lopez-Blazquez (Author), Michael Ochieng' Otieno (Author), Jesus Garcia-Foncillas (Author), Javier Martinez-Useros (Author)
• Format: Book
• Published: MDPI AG, 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Glutathione peroxidases (GPxs) are a family of enzymes that play a critical role in cellular redox homeostasis through the reduction of lipid hydroperoxides to alcohols, using glutathione as a substrate. Among them, GPx4 is particularly of interest in the regulation of ferroptosis, a form of iron-de...