Accelerated detection of mycolactone production and response to antibiotic treatment in a mouse model of Mycobacterium ulcerans disease.

• Main Authors: Paul J Converse (Author), Yalan Xing (Author), Ki Hyun Kim (Author), Sandeep Tyagi (Author), Si-Yang Li (Author), Deepak V Almeida (Author), Eric L Nuermberger (Author), Jacques H Grosset (Author), Yoshito Kishi (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Diagnosis of the neglected tropical disease, Buruli ulcer, can be made by acid-fast smear microscopy, specimen culture on mycobacterial growth media, polymerase chain reaction (PCR), and/or histopathology. All have drawbacks, including non-specificity and requirements for prolonged culture at 32°C,...