Dissecting the molecular basis of high viscosity of monospecific and bispecific IgG antibodies

• Principais autores: Cholpon Tilegenova (Autor), Saeed Izadi (Autor), Jianping Yin (Autor), Christine S. Huang (Autor), Jiansheng Wu (Autor), Diego Ellerman (Autor), Sarah G. Hymowitz (Autor), Benjamin Walters (Autor), Cleo Salisbury (Autor), Paul J. Carter (Autor)
• Formato: Livro
• Publicado em: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Some antibodies exhibit elevated viscosity at high concentrations, making them poorly suited for therapeutic applications requiring administration by injection such as subcutaneous or ocular delivery. Here we studied an anti-IL-13/IL-17 bispecific IgG4 antibody, which has anomalously high viscosity...