Dissecting the molecular basis of high viscosity of monospecific and bispecific IgG antibodies

• Main Authors: Cholpon Tilegenova (Author), Saeed Izadi (Author), Jianping Yin (Author), Christine S. Huang (Author), Jiansheng Wu (Author), Diego Ellerman (Author), Sarah G. Hymowitz (Author), Benjamin Walters (Author), Cleo Salisbury (Author), Paul J. Carter (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Some antibodies exhibit elevated viscosity at high concentrations, making them poorly suited for therapeutic applications requiring administration by injection such as subcutaneous or ocular delivery. Here we studied an anti-IL-13/IL-17 bispecific IgG4 antibody, which has anomalously high viscosity...