Comparison of soluble guanylate cyclase stimulators and activators in models of cardiovascular disease associated with oxidative stress

• Main Authors: Melissa H Costell (Author), Nicolas eAncellin (Author), Roberta E Bernard (Author), Shufang eZhao (Author), John J Upson (Author), Lisa A Morgan (Author), Kristeen eHauk (Author), Alan R Olzinski (Author), Victoria L T Ballard (Author), Kenny eHerry (Author), Pascal eGrondin (Author), Nerina eDodic (Author), Olivier eMirguet (Author), Anne eBouillot (Author), Francoise eGellibert (Author), Robert W Coatney (Author), John J Lepore (Author), Beat M. Jucker (Author), Larry J Jolivette (Author), Robert N Willette (Author), Christine G Schnackenberg (Author), David J Behm (Author)
• Format: Bog
• Udgivet: Frontiers Media S.A., 2012-07-01T00:00:00Z.
• Fag: article
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Soluble guanylate cyclase (sGC), the primary mediator of nitric oxide (NO) bioactivity, exists as reduced (NO-sensitive) and oxidized (NO-insensitive) forms. We tested the hypothesis that the cardiovascular protective effects of NO-insensitive sGC activation would be potentiated under conditions of...