Cyclocreatine Phosphate: A Novel Bioenergetic/Anti-Inflammatory Drug That Resuscitates Poorly Functioning Hearts and Protects against Development of Heart Failure

• Main Authors: Salwa A. Elgebaly (Author), Charles Van Buren (Author), Robert Todd (Author), Robert Poston (Author), Reem K. Arafa (Author), Nashwa El-Khazragy (Author), Donald Kreutzer (Author), Mostafa A. Rabie (Author), Ahmed F. Mohamed (Author), Lamiaa A. Ahmed (Author), Nesrine S. El Sayed (Author)
• Format: Book
• Published: MDPI AG, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Irreversible myocardial injury causes the exhaustion of cellular adenosine triphosphate (ATP) contributing to heart failure (HF). Cyclocreatine phosphate (CCrP) was shown to preserve myocardial ATP during ischemia and maintain cardiac function in various animal models of ischemia/reperfusion. We tes...