LCâMS/MS assay for the determination of natamycin in rabbit and human plasma: Application to a pharmacokinetics and protein binding study

• Main Authors: Yashpal Singh Chhonker (Author), Devendra Kumar (Author), Pankaj Shrivastava (Author), Deepak Kumar (Author), Rajbir Singh (Author), Hardik Chandasana (Author), Rabi Sankar Bhatta (Author)
• Format: Book
• Published: Elsevier, 2013-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

To enable reliable quantification of natamycin in rabbit and human plasma, a validated, sensitive and selective liquid chromatographyâtandem mass spectrometry assay was developed. The chromatographic separation was achieved isocratically on a Cyano column using methanol: aqueous 3.5 mM ammonium ace...