The Discovery of RNA Aptamers that Selectively Bind Glioblastoma Stem Cells

• Main Authors: Alessandra Affinito (Author), Cristina Quintavalle (Author), Carla Lucia Esposito (Author), Giuseppina Roscigno (Author), Claudia Vilardo (Author), Silvia Nuzzo (Author), Lucia Ricci-Vitiani (Author), Gabriele De Luca (Author), Roberto Pallini (Author), Anna S. Kichkailo (Author), Ivan N. Lapin (Author), Vittorio de Franciscis (Author), Gerolama Condorelli (Author)
• Format: Book
• Published: Elsevier, 2019-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Glioblastoma (GBM) is the most aggressive primary brain tumor in adults. Despite progress in surgical and medical neuro-oncology, prognosis for GBM patients remains dismal, with a median survival of only 14-15 months. The modest benefit of conventional therapies is due to the presence of GBM stem ce...