Identification of New Rofecoxib-Based Cyclooxygenase-2 Inhibitors: A Bioinformatics Approach

• Autori principali: Rozires P. Leão (Autore), Josiane V. Cruz (Autore), Glauber V. da Costa (Autore), Jorddy N. Cruz (Autore), Elenilze F. B. Ferreira (Autore), Raí C. Silva (Autore), Lúcio R. de Lima (Autore), Rosivaldo S. Borges (Autore), Gabriela B. dos Santos (Autore), Cleydson B. R. Santos (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2020-08-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

The cyclooxygenase-2 receptor is a therapeutic target for planning potential drugs with anti-inflammatory activity. The selective cyclooxygenase-2 (COX-2) inhibitor rofecoxib was selected as a pivot molecule to perform virtual ligand-based screening from six commercial databases. We performed the se...