A human pluripotent stem cell model of catecholaminergic polymorphic ventricular tachycardia recapitulates patient-specific drug responses

• Main Authors: Marcela K. Preininger (Author), Rajneesh Jha (Author), Joshua T. Maxwell (Author), Qingling Wu (Author), Monalisa Singh (Author), Bo Wang (Author), Aarti Dalal (Author), Zachary T. Mceachin (Author), Wilfried Rossoll (Author), Chadwick M. Hales (Author), Peter S. Fischbach (Author), Mary B. Wagner (Author), Chunhui Xu (Author)
• Format: Book
• Published: The Company of Biologists, 2016-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Although β-blockers can be used to eliminate stress-induced ventricular arrhythmias in patients with catecholaminergic polymorphic ventricular tachycardia (CPVT), this treatment is unsuccessful in ∼25% of cases. Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) generated from these pat...