Evidence for a Specific Intracellular Localization of an Antisense Oligonucleotide in K562 Cells

• Main Authors: M. Helena Vasconcelos (Author), Luis F. Maia (Author), Cristina Sousa (Author), Sandra S. Beleza (Author), José E. Guimarães (Author)
• Format: Book
• Published: Elsevier, 2005-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In order to be active, antisense oligonucleotides (ASOs) should be delivered to the nuclei of cells. The lack of effect of some ASOs might be explained by poor distribution inside the cell. Here we describe the study of the intracellular distribution of an ASO in a leukemic cell line in which the AS...