Aminophylline Induces Two Types of Arrhythmic Events in Human Pluripotent Stem Cell-Derived Cardiomyocytes

• Main Authors: Simon Klimovic (Author), Martin Scurek (Author), Martin Pesl (Author), Deborah Beckerova (Author), Sarka Jelinkova (Author), Tomas Urban (Author), Daniil Kabanov (Author), Zdenek Starek (Author), Marketa Bebarova (Author), Jan Pribyl (Author), Vladimir Rotrekl (Author), Kristian Brat (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cardiac side effects of some pulmonary drugs are observed in clinical practice. Aminophylline, a methylxanthine bronchodilator with documented proarrhythmic action, may serve as an example. Data on the action of aminophylline on cardiac cell electrophysiology and contractility are not available. Hen...