New isoxazolidinyl-based N-alkylethanolamines as new activators of human brain carbonic anhydrases

• Main Authors: Doretta Cuffaro (Author), Riccardo Di Leo (Author), Lidia Ciccone (Author), Alessio Nocentini (Author), Claudiu T. Supuran (Author), Elisa Nuti (Author), Armando Rossello (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Carbonic anhydrases (CAs) are widespread metalloenzymes which catalyse the reversible hydration of carbon dioxide (CO2) to bicarbonate (HCO3−) and a proton, relevant in many physiological processes. In the last few years, the involvement of CA activation in different metabolic pathways in the human...