A Novel Hydroxamate-Based Compound WMJ-J-09 Causes Head and Neck Squamous Cell Carcinoma Cell Death via LKB1-AMPK-p38MAPK-p63-Survivin Cascade

• Main Authors: Chia-Sheng Yen (Author), Cheuk-Sing Choy (Author), Wei-Jan Huang (Author), Shiu-Wen Huang (Author), Pin-Ye Lai (Author), Meng-Chieh Yu (Author), Ching Shiue (Author), Ya-Fen Hsu (Author), Ming-Jen Hsu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Growing evidence shows that hydroxamate-based compounds exhibit broad-spectrum pharmacological properties including anti-tumor activity. However, the precise mechanisms underlying hydroxamate derivative-induced cancer cell death remain incomplete understood. In this study, we explored the anti-tumor...