Genome-wide analysis of androgen receptor binding and transcriptomic analysis in mesenchymal subsets during prostate development

• Main Authors: Claire Nash (Author), Nadia Boufaied (Author), Dunarel Badescu (Author), Yu Chang Wang (Author), Miltiadis Paliouras (Author), Mark Trifiro (Author), Ioannis Ragoussis (Author), Axel A. Thomson (Author)
• Format: Book
• Published: The Company of Biologists, 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Prostate development is controlled by androgens, the androgen receptor (AR) and mesenchymal-epithelial signalling. We used chromatin immunoprecipitation sequencing (ChIP-seq) to define AR genomic binding in the male and female mesenchyme. Tissue- and single-cell-based transcriptional profiling was u...