Comparison of Doxycycline, Minocycline, Doxycycline plus Albendazole and Albendazole Alone in Their Efficacy against Onchocerciasis in a Randomized, Open-Label, Pilot Trial.

• Main Authors: Ute Klarmann-Schulz (Author), Sabine Specht (Author), Alexander Yaw Debrah (Author), Linda Batsa (Author), Nana Kwame Ayisi-Boateng (Author), Jubin Osei-Mensah (Author), Yusif Mubarik (Author), Peter Konadu (Author), Arcangelo Ricchiuto (Author), Rolf Fimmers (Author), Sandra Arriens (Author), Bettina Dubben (Author), Louise Ford (Author), Mark Taylor (Author), Achim Hoerauf (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The search for new macrofilaricidal drugs against onchocerciasis that can be administered in shorter regimens than required for doxycycline (DOX, 200mg/d given for 4-6 weeks), identified minocycline (MIN) with superior efficacy to DOX. Further reduction in the treatment regimen may be achieved with...