Translation Regulation and RNA Granule Formation after Heat Shock of Procyclic Form Trypanosoma brucei: Many Heat-Induced mRNAs Are also Increased during Differentiation to Mammalian-Infective Forms.

• Principais autores: Igor Minia (Autor), Clementine Merce (Autor), Monica Terrao (Autor), Christine Clayton (Autor)
• Formato: Livro
• Publicado em: Public Library of Science (PLoS), 2016-09-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

African trypanosome procyclic forms multiply in the midgut of tsetse flies, and are routinely cultured at 27°C. Heat shocks of 37°C and above result in general inhibition of translation, and severe heat shock (41°C) results in sequestration of mRNA in granules. The mRNAs that are bound by the zinc-f...