Phthalimide Derivative Shows Anti-angiogenic Activity in a 3D Microfluidic Model and No Teratogenicity in Zebrafish Embryos

• Main Authors: Annalisa Mercurio (Author), Lucy Sharples (Author), Filomena Corbo (Author), Carlo Franchini (Author), Angelo Vacca (Author), Alessia Catalano (Author), Alessia Carocci (Author), Roger D. Kamm (Author), Andrea Pavesi (Author), Giulia Adriani (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Angiogenesis is a crucial event for tumor progression and metastasis. It is the process through which new blood vessels are formed and has become a therapeutic target in many cancer therapies. However, current anti-angiogenic drugs such as Thalidomide still have detrimental teratogenic effects. This...