Protective efficacy of a Plasmodium vivax circumsporozoite protein-based vaccine in Aotus nancymaae is associated with antibodies to the repeat region.

• Main Authors: Anjali Yadava (Author), Cysha E Hall (Author), JoAnn S Sullivan (Author), Douglas Nace (Author), Tyrone Williams (Author), William E Collins (Author), Christian F Ockenhouse (Author), John W Barnwell (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We have previously reported that Vivax Malaria Protein 001 (VMP001), a vaccine candidate based on the circumsporozoite protein of Plasmodium vivax, is immunogenic in mice and rhesus monkeys in the presence of various adjuvants. In the present study, we evaluated the immunogenicity and efficacy of VM...