High Fat Diet-Induced Hepatic 18-Carbon Fatty Acids Accumulation Up-Regulates CYP2A5/CYP2A6 via NF-E2-Related Factor 2

• Main Authors: Xing-he Wang (Author), Xiao-xu Cui (Author), Xiao-qi Sun (Author), Xing-hui Wang (Author), Xiao-chong Li (Author), Yue Qi (Author), Wei Li (Author), Mei-yu Han (Author), Ishfaq Muhammad (Author), Xiu-ying Zhang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

To investigate the role of hepatic 18-carbon fatty acids (FA) accumulation in regulating CYP2A5/2A6 and the significance of Nrf2 in the process during hepatocytes steatosis, Nrf2-null, and wild type mice fed with high-fat diet (HFD), and Nrf2 silenced or over expressed HepG2 cells administered with...