Case report: A case of severe capecitabine toxicity due to confirmed in trans compound heterozygosity of a common and rare DPYD variant

• Main Authors: Amy de Haar-Holleman (Author), Pieter-Jan Cortoos (Author), Jelle Vlaeminck (Author), Paulien Van Landuyt (Author), Stephane Steurbaut (Author), Freya Vaeyens (Author), Vincent Haufroid (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Variations in the activity of the enzyme dihydropyrimidine dehydrogenase (DPD) are associated with toxicity to fluoropyrimidine-containing chemotherapy. Testing of DPD deficiency either by targeted genotyping of the corresponding DPYD gene or by quantification of plasma concentration of uracil and d...