Heme crystallization in a Chagas disease vector acts as a redox-protective mechanism to allow insect reproduction and parasite infection.

• Main Authors: Caroline M Ferreira (Author), Renata Stiebler (Author), Francis M Saraiva (Author), Guilherme C Lechuga (Author), Ana Beatriz Walter-Nuno (Author), Saulo C Bourguignon (Author), Marcelo S Gonzalez (Author), Patrícia Azambuja (Author), Ana Caroline P Gandara (Author), Rubem F S Menna-Barreto (Author), Gabriela O Paiva-Silva (Author), Marcia C Paes (Author), Marcus F Oliveira (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Heme crystallization as hemozoin represents the dominant mechanism of heme disposal in blood feeding triatomine insect vectors of the Chagas disease. The absence of drugs or vaccine for the Chagas disease causative agent, the parasite Trypanosoma cruzi, makes the control of vector population the bes...