A Guinea Pig Model of Airway Smooth Muscle Hyperreactivity Induced by Chronic Allergic Lung Inflammation: Contribution of Epithelium and Oxidative Stress

• Main Authors: Luiz Henrique César Vasconcelos (Author), Maria da Conceição Correia Silva (Author), Alana Cristina Costa (Author), Giuliana Amanda de Oliveira (Author), Iara Leão Luna de Souza (Author), Fernando Ramos Queiroga (Author), Layanne Cabral da Cunha Araujo (Author), Glêbia Alexa Cardoso (Author), Renato Fraga Righetti (Author), Alexandre Sérgio Silva (Author), Patrícia Mirella da Silva (Author), Carla Roberta de Oliveira Carvalho (Author), Giciane Carvalho Vieira (Author), Iolanda de Fátima Lopes Calvo Tibério (Author), Fabiana de Andrade Cavalcante (Author), Bagnólia Araújo da Silva (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Asthma is a heterogeneous disease of the airways characterized by chronic inflammation associated with bronchial and smooth muscle hyperresponsiveness. Currently, different murine models for the study of asthma show poor bronchial hyperresponsiveness due to a scarcity of smooth muscle and large airw...