Identification of risk variants related to malignant tumors in children with birth defects by whole genome sequencing

• Main Authors: Yichuan Liu (Author), Hui-Qi Qu (Author), Xiao Chang (Author), Frank D Mentch (Author), Haijun Qiu (Author), Kenny Nguyen (Author), Xiang Wang (Author), Amir Hossein Saeidian (Author), Deborah Watson (Author), Joseph Glessner (Author), Hakon Hakonarson (Author)
• Formato: Libro
• Publicado: BMC, 2022-11-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

Abstract Background Children with birth defects (BD) are more likely to develop cancer and the increased risk of cancer persists into adulthood. Prior population-based assessments have demonstrated that even non-chromosomal BDs are associated with at least two-fold increase of cancer risk. Identific...