Systematically optimized topical delivery system for Loperamide hydrochloride: Formulation design, in vitro and in vivo biopharmaceutical evaluation

• Egile Nagusiak: Jianhui Shu (Egilea), Jingjing Zhao (Egilea), Fang Guo (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2018-05-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

This study aimed to develop a suitable topical delivery system containing diethylene glycol monoethyl ether (DGME) for Loperamide hydrochloride (Lop). Two factors, three levels Central-Composite design were applied by generating a quadratic polynomial equation to form contour plots and response surf...