Pgc-1α controls epidermal stem cell fate and skin repair by sustaining NAD+ homeostasis during aging

Pgc-1α controls epidermal stem cell fate and skin repair by sustaining NAD+ homeostasis during aging

Objective: The epidermal barrier is renewed by the activation, proliferation, and differentiation of keratinocyte stem cells after injury and aging impedes this repair process through undefined mechanisms. We previously identified a gene signature of metabolic dysfunction in aged murine epidermis, b...

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Main Authors: Wesley Wong (Author), Elizabeth D. Crane (Author), Hui Zhang (Author), Jiahe Li (Author), Tovah A. Day (Author), Alex E. Green (Author), Keir J. Menzies (Author), Justin D. Crane (Author)
Format: Book
Published: Elsevier, 2022-11-01T00:00:00Z.
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